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Yeah, I made a framework called Jump Start NGUI to help with my GUI systems. I led a project last year that was very heavy GUI with it. :)
NGUI allows you to make a GUI system that scales to your screen size. As long as you don't crowd your GUI, it will scale to any mobile device's size. You can test your GUI by switching to the platform you want and then change resolutions in the game screen's top left corner (probably know that...but other people on this subreddit might not).