That's a good ep. If you have any interest at all I suggest picking up Newby's book. It's a real quick read, very informative, and well-sourced:
You need to understand the history of the Lyme Disease first and foremost, and understand how they created Lyme disease to understand why you’re asking the wrong questions.
Bitten: The Secret History of Lyme Disease and Biological Weapons: https://www.amazon.com/dp/0062896288/ref=cm_sw_em_r_mt_dp_BJD433QVT38NJ0F9533F
What you should be asking is where did Lyme disease come from? Why did these bacterium not cause serious illness in humans until the 1960’s?
The statistical analysis of the genetic mutations of the bacterium will not tell you the functional changes of the bacterium or their ability to cause illness and disease. Even a 1% or less genetic mutation could be the functional difference between something being ineffective or causing a severe illness or disease.
It also fails to consider that “Lyme disease” is NOT a single infection, but a collection of co-infections. The co-infection profile varies from tick to tick, and person to person. Lyme disease is caused by a cocktail of infections, and to hyper focus on one specific spirochete is not logical when considering the big picture of what Lyme disease is, how it came to be, and why it causes such severe illness today.
https://www.amazon.com/dp/0062896288/ref=cm_sw_em_r_mt_dp_6HEE9PX2533RFPJ8XNXF
It’s a bioweapon. The guy who created it confessed on his death bed.
Even he got infected and possibly died from the disease.