What is Reddit's opinion of CariFree Gel 1100 (Mint) Anti-Cavity Fluoride Toothpaste with Nano Hydroxyapatite, Cavity Prevention and Enamel Protection, Dentist Recommended for Kids and Adults, 2.40 oz.?

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Not the original commenter, but this is the one my dentist recommended and I use!

https://www.amazon.com/gp/product/B00QJA4GB4

CariFree CTx4 is the brand of toothpaste containing nano-hydroxyapatite that I use. NHA is arguably superior to NovaMin as used in European sensodyne, but I think there's enough research to show that both are superior to plain fluoride.

Carifree actually has a whole suite of products like mouthwash, xylitol gums, mouth-wetting sprays for dry-mouth, etc, that they've developed into an anti-cavity program that some dentists 'prescribe' their high-risk patients.

Here's some of the studies:

• Enamel surface remineralization: Using synthetic nanohydroxyapatite

>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636833/

>The use of biomimetic nanohydroxyapatite as a remineralizing agent holds promise as a new synthetic enamel biocompatible material to repair early carious lesions.

• Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature

>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252862/

>The nano-hydroxyapatite is a revolutionary material with a wide use in dentistry. With regard to restorative and preventive fields, nano-hydroxyapatite has remarkable remineralizing effects on initial lesions of enamel, certainly higher than traditional fluorides used until now for this purpose. Nano-hydroxyapatite is, in fact, a better source of free Ca, and this is a key element as regards the remineralization, the protection against caries and dental erosion.

• Enamel surface remineralization: Using synthetic nanohydroxyapatite.

>https://www.ncbi.nlm.nih.gov/pubmed/23633804

>Thirty sound human premolars were divided into nanohydroxyapatite group (n = 15) and the sodium fluoride group (n = 15)...The results showed that the nanohydroxyapatite group produced a surface morphology close to the biologic enamel, the increase in mineral content (Ca/P ratio) was more significant in the nanohydroxyapatite group (P < 0.05) and the SMH recovery was closer to the baseline level in the nanohydroxyapatite group (P < 0.05).

• In vitro effects of nano-hydroxyapatite paste on initial enamel carious lesions.

>https://www.ncbi.nlm.nih.gov/pubmed/24960376

>Forty-eight human enamel blocks were assigned to four groups (N=12): (1) control (without agent); (2) fluoride varnish (Duraphat); (3) nano-HAP paste (Desensibilize Nano P); and (4) casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste (MI Paste Plus)...After the cariogenic challenge, the nano-HAP group showed significantly higher KHN and %SMHR values than varnish. The CPP-ACP group showed no increase in KHN. The nano-HAP group showed, via AFM, a protective layer formation with globular deposits on the surface....SMHR and AFM morphology revealed that nano-hydroxyapatite paste showed a protective effect against in vitro enamel caries development.

• Remineralization of early caries by a nano-hydroxyapatite dentifrice.

>https://www.ncbi.nlm.nih.gov/pubmed/22403978

>nHAP dentifrice caused remineralization comparable to a fluoride dentifrice, and inhibited caries development, thus suggesting that an nHAP dentifrice can be an effective alternative to fluoride toothpaste.

• An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study.

>https://www.ncbi.nlm.nih.gov/pubmed/27891458

>It was concluded that all the three desensiting agents were effective in the dentine tubule occlusion. In addition efficacy of nano-hydroxyapatite toothpaste was greater compared to the other desensiting agents.

Novamin seems somewhat similar, it's a "bioglass" that is supposed to fill gaps in enamel and reduce tooth sensitivity, though it may also promote remineralization. Like I said, it's in sensodyne (interesting, it is not in US sensodyne, only in other countries like Canada and the UK).

• Dentinal tubules occluded by bioactive-glass containing toothpaste exhibit high resistance toward acidic soft drink challenge.

>https://www.ncbi.nlm.nih.gov/pubmed/27813093

>The scoring and the percentage of occluded dentinal tubules by Novamin containing toothpaste was significantly better compared to arginine or the control toothpaste.

Here's a link to that ctx4 stuff: http://www.amazon.com/CariFree-CTx4-Dentist-Recommended-Anti-Cavity/dp/B00QJA4GB4