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Jarrow Formulas Extra Strength Methyl B-12 & Methyl Folate-100 Chewable Tablet, Lemon Flavored-Bioactive Vitamin B12 & B9-Cellular Energy & Cardiovascular Support- Non-GMO & Gluten Free?
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Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12 & B9 - Supports Energy Production, Brain Function & Metabolism - Gluten Free - 100 Servings https://www.amazon.com/dp/B01IJR5VM2/ref=cm_sw_r_apan_glt_fabc_DRC6CND9YZY56FWNN69T?_encoding=UTF8&psc=1
It also has P-5-P (Vitamin B6)! All the food vitamins in bioactive form.
I've had pots for a few years and caught covid about 2 months ago, unvaccinated. It was really mild and I was able to move around still, but after it cleared up, my POTS symptoms were worse. I'm just now starting to feel back to normal POTS. Cardiologist said it would take 2 months at the start of it all, and therapist says the more extreme depression and anxiety will also pass which it has slightly. I just kept forcing myself to move around and do chores and stretches n such. Even repotting plants, or writing. Anything you can do to not get too stagnant. Push the fluids (Hydrant/LiquidIV), take a B vitamin (I use this every morning and it helps a ton: Jarrow Formulas Methyl B-12 &... https://www.amazon.com/dp/B01IJR5VM2?ref=ppx_pop_mob_ap_share) and some vitamin C. I'm also taking Midodrine which my doctor upped the dosage since COVID lowered my blood pressure even more and also did a round of heavy steroids while sick. Might still be an option for you. Hope any of this helps.
Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12 & B9 - Supports Energy Production, Brain Function & Metabolism - Gluten Free - 100 Servings https://www.amazon.com/dp/B01IJR5VM2/ref=cm_sw_r_cp_api_glt_fabc_SQNT60YNV8SB25M2XFNY?_encoding=UTF8&psc=1
The Jarrow is a melt/chew (I'm pretty sure). I have methylation issues so I try to get pre methylated with those three.
I just found some tabled that are 50 mg thiamin sublingual melts (the bar &ez melts and liquid were much lower in active vitamins).
I'll give it a shot and see how it works. I can't use any of the normal N stuff, or even caffeine.
Thanks for your very detailed description I f how you use.
>I personally had a horrible experience with the jarrow brand. The tablets didn't melt as advertised.
I'm not sure about 'melting' but these B12+Folate+B6 Jarrow chewables work great. Sometimes I throw them in my smoothie but often I just eat them since the taste is fine.
B-12(1,000 mcgmethyl) - Folate - B-6(1.5mcg, 75% DV)
Almost everything else that I have found has B-6 at around 400% DV or more. I know its not all the B's, but it is a good start.
https://www.amazon.com/gp/product/B01IJR5VM2/ref=s9_acsd_hps_bw_c_x_7_w
Stop taking both and when you return to baseline, add in one for a bit and see if the symptoms persist. Then you will have your answer as to what is causing the "rage".
To finally answer your question, nope. Noopept does not make me rage. I do enjoy a little rage from time to time though. Something is obviously not in balance.
"Good, good. Let the hate flow through you." :)
Chris Masterjohn has a comprehensive guide for dealing with the various MTHFR polymorphisms and the dietary factors you can focus on.
For a supplement, I recommend Jarrow B12/Folate/P5P.
>PLP, the active form of B6 is only found in animal products. Organ meats are particularly high. Plants, and almost all supplements will contain the inactive form which must be converted after ingestion.
This is not an accurate description of the vitamin, it's isomers, or their presence in nature. Here is the NASEM page for B6 which contains much more information.
>Vitamin B6 (B6) comprises a group of six related compounds: pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM), and their respective 5'-phosphates (PLP, PNP, and PMP). The major forms in animal tissues are PLP and PMP; plant-derived foods contain primarily PN and PNP, sometimes in the form of a glucoside. In humans, the major excretory form is 4-pyridoxic acid (4-PA).
>....
>In animal tissue the major form of B6 is PLP; next is PMP. Absorption in the gut involves phosphatase-mediated hydrolysis followed by transport of the nonphosphorylated form into the mucosal cell. Transport is by a nonsaturable passive diffusion mechanism. Even extremely large doses are well absorbed (Hamm et al., 1979). PN glucoside is absorbed less effectively than are PLP and PMP and, in humans, is deconjugated by a mucosal glucosidase (Nakano and Gregory, 1997). Some PN glucoside is absorbed intact and can be hydrolyzed in various tissues.
>....
>Extrapolation of data from studies with experimental animals to assess the B6 requirement for maintenance and growth (Coburn et al., 1987, 1988b) indicates that 1 mg of PN would be an adequate intake for the adult. Modeling of human B6 pools has also led to an assessment of a minimum requirement of about 0.4 mg/day of PN (Coburn, 1990).
>....
>The plasma PLP concentration generally correlates with other indices of B6 status. PLP is the major form of B6 in tissues and is the active coenzyme species. In animals fed graded levels of pyridoxine (PN), the plasma PLP concentration correlated well with tissue B6 (Lumeng et al., 1978).
There is zero evidence in the literature that people are unable to obtain sufficient B6 from a plant-based diet.
>There are some Genetic mutations which limit the conversion of inactive B6 to active. Some result in severe symptoms. I'm sure there are others.
Your link mentions a genetic mutation that has occurred in 14 people. Total. Ever. Also, this condition presents itself as epileptic seizures shortly before or after birth. So if you had this (two-in-a-billion chance) then you would already know it.
I will echo your statement about P5P (currently) being the best form to supplement with since most supplemental B6 is given in high doses and there is some preliminary research indicating that high doses of pyridoxine can interfere with B6 function. Note that this was an in vitro study so much more research needs done but if you are going to bother with a supplement you might as well avoid the pyridoxine form at this point. Jarrow makes a good B12/folate/B6 supplement for those interested. I personally avoid high-dosing of any supplemental forms since these are doses that have not been seen in the human genetic history and we are constantly learning about previously-unknown negative impacts of large doses of vitamins and minerals. I haven't found a good B supplement that uses low doses of the good forms but I would be interested if anyone has found any!
I too wanted this information and am currently in day 4 of being off Effexor. First a couple things that helped me, methyl folate+methyl b12. It’s one pill but folate is needed for the synthesis of norepinephrine, serotonin and dopamine. If you have the MTHFR gene mutation you don’t make enough of this on your own so take extra! I take 2 a day for this reason. Link to buy. I also take Zyrtec (or the generic cetirizine HCL) and it seems to help. I’ve heard Benadryl Is more useful here because it is actually an ssri. I can take Benadryl without it knocking me out most of the time, but I care for young kids so I can’t risk the sleepiness at this moment so I can’t speak to that method but many on this forum say Benadryl works well.
Here’s a bit about the why and how from this article source: discontinuation syndrome
“withdrawal” is the incorrect way to describe discontinuation symptoms; antidepressant medications are not believed to be habit forming and are not associated with drug-seeking behavior.13 Long-term use of SSRIs increases synaptic levels of serotonin through blockade of the serotonin reuptake pump, resulting in down-regulation of postsynaptic receptors.14
There is speculation concerning the possibility of a temporary deficiency of synaptic serotonin with abrupt withdrawal of an SSRI. This deficiency is compounded by the fact that down-regulated receptors will remain in their relatively hypoactive state for days to weeks.
And here is a link for methyl folate and it’s role in our brains. In case you wanted more info! Folate
Sorry you are going through this. I feel your pain as I’m just a day behind you. I was only on 150 for about 5 months so I may be lucky here but taking those two supplements every morning has been WAY helpful. Probably reduced my symptoms by 40% or more. I didn’t discover this until I tried it yesterday and felt better within the hour. Best of luck to you. 💜
You have got to start eating good food and go out in the sun a bit every day at midday if you have any sun in your area, even 15 minutes helps a lot, let the sun touch your skin directly. Take vit d pills and you need to take them with a fat source, the body cannot digest fat soluble vitamins without you eating fat at the same time.
I would really suggest you try to avoid grain oils too and target coconut oil/cream and cacao oil (good quality chocolate) and see if that helps, but chocolate only if you are taking the b vites with b1 at a separate time, chocolate has good things but depletes b1, which is not a prob if you have plenty of b1 in you first.
Anyway, coconut oil is a good one to start with, it feeds the mitochondria nicely and kills harmful gut bacteria, just start slow and back off if your gut gets upset, you don't want to change gut bacteria TOO fast, just a bit at a time if your gut gets mad and slowly work your way up. Since coconut oil is a fat, you can take it with your vitamin D pills to make sure they digest. So yeah, just a bit of coconut oil with your D pills to start with and see how it goes. For b vit sublinguals, I use this one from amazon: https://www.amazon.com/gp/product/B01IJR5VM2/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1 and I also like this one for b1: https://www.amazon.com/gp/product/B00VVLAPKM/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1 Magnesium is another one a lot of peeps are very much too low on.
YOu may well feel like shite right now but could feel a lot better if you fix your vitamin status, maybe consider taking just one or two classes instead of a full load. Make the other half of your job working on your health. If you find out all of what you are lacking and start taking it, you could feel better pretty quickly too.
Thanks man for your thoughtful reply.
I have a couple questions, if you don't mind:
Is this a good methylfolate + B12 product? It contains 1000mcg of b12, 400mcg of folate and also 1.5mg of B6 P-5-P
https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2?th=1Is it true that B12 depletes potassium?
I've heard that it's usually advised to not supplement specific B vitamins alone and it's better to take a B complex, is it true?
Related to this, is it necessary to take a methylated B complex when supplementing with SAMe or TMG?Let's suppose I'm under-methylated (since I'm having many symptoms): could this explain not only high histamine and hay fever, but also other issues I'm having, i.e. ADHD/focus issues and constant overthinking and worrying?
Do you think that these supplements (methylfolate, b12, TMG, SAMe) could help with these problems, or do you have other suggestions?
I'm still trying to figure out if my issues are related to low serotonin, dopamine or both. I suspect I have also high acetylcholine, since I have high REM sleep vs low deep sleep, high saliva production and cold hands.
​
Sorry for all these questions, but the topic of methylation is quite complex!
Thanks
https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2
One of these, they’re supposed to be the more bioavailable forms. Probably any type of bcomplex would work though
https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2
Just try this one today, half a pill, no effect for now, will try the dosage you suggest, thanks again!
Is it this one? I have recently been taking this as well and am loving the convenience of a chewable two-in-one.
>I went to the doctor because of the crushing fatigue I experience most days. Could this be a reason?
Without knowing your specific blood results it's hard to be sure, but B12 and folate deficiencies both have fatigue as a common symptom. MANY vitamin and mineral deficiencies can result in fatigue though, so it's hard to narrow down. Did they test your D levels? Hormone or lipid panels?
>How long will it take to correct this stuff if I start supplementing?
The symptoms should resolve within a week. I would recommend superloading for a few days to quickly bring your levels back up (one tablet in the morning and one in the evening, with or without food). After a week or two, you can cut back to a single daily dose, then get retested again in 4-6 months.
Also, how is your 'beans and greens' intake? I would bump those up as much as possible since they are great sources of food folate and also come with plenty of other beneficial nutrients.
50mg of p5p is a high dose. you only need 1-2mg. try this https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2/ref=sr_1_6_s_it?s=hpc&ie=UTF8&qid=1523494293&sr=1-6&keywords=jarrow+methyl+b12
Thank u...for your help...
I have added this to my list to purchase, after I run out of my current b12.
https://www.amazon.com/Jarrow-Formulas-Pyridoxal-5-phosphate-Lozenges-Supports/dp/B01IJR5VM2