I am a therapist and I have worked with schizophrenia in my practice and so has my wife in her clinical experience. The thing I will say is that schizophrenia definitely varies by the individual and the case. Medication can be a frustrating part for of treatment due to all of the side effects. It isn't to say that it doesn't help, but it can be frustrating to a person who is used to having a normal life and then all the sudden a medication causes all sorts of other symptoms. I would suggest for you to read both of the following books and look for a support group. Also, it will be important for your sister to have regular social interaction. In Austin we have something called Austin Clubhouse that helps with all of this and is a free service. I would look for services similar to this. The regular interaction will help her to have meaning and to move towards her goals -- even if they have shifted a bit. I hope that helps. This is a life altering shift for you, her, and your family. It takes time.