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I brought my Osprey Farpoint40 on a 6 week trip in SE Asia and it was and still is great. You can carry it on planes and buses and its less cumbersome.
The 55L one I think is basically the 40 and a 15L daypack, which could be handy to have.
If I could do it over again I'd get the Osprey Farpoint 40. The Porter 45 itself has a lot of extra material that makes it a bit less efficient. Great bag nonetheless and not worth effort for me to change gear right now.
I traveled long term with this pack and loved it: [link]