I've worked in the States (Portland, Texas, Florida), Europe (Germany) and the Middle East (Abu Dhabi for planning, Afghanistan for infrastructure planning). I won't speak for all urban planners/designers, and this is just for fun, *IF* SimCity were real of course, your design choices have the following positives:
Legibility - people have wayfinding; "where do you live?"/"I live just off the industrial district opposite Logas River" See placemaking and ethos with Kevin Lynch.
Sense of Scale - the ability to know what part of a city you desire; some people like horrible commutes in exchange for more space vs people that don't want to cook so they don't need a huge kitchen, just able to walk to a near shop; understanding scale.
Limited Division - a key failure in urban planning is when you see walls between houses and highways. Addressing the most vulnerable users of the transportation system (people over cars) increases placemaking and economic efficiency.
Suburban realization - If I could get rid of surburbia IRL, I would, but you have recognized that it is never going to happen soon, so you created an urban core with a mid-density buffer, and your suburban streets are well connected allowing for pedestrians and cyclists (I know, it's SC4 not reality), without doing "ladder developments." Key to your region would be to make a transit center that connects to your regional neighbors (including ferry for the future). The game has its limitations, but it would be nice to see visually.
Heirarchy - You have a nice heirarchy of 1) regional, 2) district, and 3) neighborhood centers. SC4 doesn't care about that, but I do. Maybe throw some police kiosks and small clinics around out there. Add your usual regional stuff - municipal airport, etc. on the other side of the river.
Consider better integration. You clearly have clean (HD) industry demand, it's okay to locate some in the periphery of downtown to allow for short trips. SC4 doesn't apply value to waterfront, but it would be nice to see trails or other amenities along it.
Again: This is just for fun, and it's a game with its limitations. I just like what I saw.