It's definitely possible, and I'd argue it's a lot simpler than most languages. A few months back I played around with Boa Constructor, which basically builds wxpython GUI's for you. It doesn't get much simpler than that. If you're going for a smaller project, the builtin python module tkinter is very easy to use as well.
tl;dr: yes.
edit: Not IDE's, GUI's. Pretty critical mistake, my bad.
It exists, but has been very unfortunately frozen in time in 2007: Boa Constructor. It was developed exactly as a "Delphi for Python". The screenshots are otherworldly in how out of date they are (some still show its name prior to Boa, and I think maybe some Windows 2000 is on there?). It (v. 0.6.1) will still work very well with Python 2.5 and wxPython 2.8.10 but I don't think it will work with > 2.6. or wxPython 2.9+. I basically learned Python on it, still use it, and did a video tutorial series about it.
I would love it if it could be resurrected. The lone developer just hasn't had the time since the earlier years. It would be great if it could be brought back with others' help. Some had attempted a fork, but I don't think anything panned out. I think it would need the oversight of the original developer.
The form designer specifically might be as easy or easier than VB6. But VB6's GUI building process isn't just about drawing buttons on forms, but double clicking on said buttons and having the code editor pop up with the handler function already declared and the cursor already in a position where you type code. And while you type said code, the editor makes sure you format it properly, tries to help you by showing relevant functions, subroutines and properties (all with nice icons and such) and even having two nice combo boxes that list all available objects and events/methods for these objects right up there without eating more screen real estate than a couple dozen pixels vertically. Moreover, pressing F1 anywhere in the code or the form designer gets you relevant help fast, with example use, syntax and no matter if you do that over a language construct, control reference or VB6-provided function.
Modern form designers are much better than VB6's designer (which is probably as basic as it can get) but the form designer was only a small part of the ease of making GUIs with VB6.
I think that Boa Constructor is closer to what the OP wants. Although i haven't tried it myself, it seems like a RAD IDE like VB6 and Delphi (and Lazarus, if you want something open source).