I'm a big fan of GlimmerBlocker. It's a prefpane, not a browser extension, so it works system wide and doesn't need to be updated every time there's a new version of Safari. It can also be setup as a proxy for an iOS device to block ads on an iPad or iPhone.
The problem with content blockers is they only work in safari or apps built with the correct webview control.
GlimmerBlocker for OSX is free and blocks ads/trackers system wide. Weblocker is not free, but does similar for iOS. A bit less customisable tho