I've been working on some ideas for software mixing for the upcoming WOTS stream. Ideally, I'd like to be able to mix game audio, voice chat audio, and so forth.
For instance, is it possible to have my mic work for both chatting on my stream and doing in-game chat like Payday 2?
I also found this - http://www.mixxx.org/manual/latest/index.html which appears to work on Windows and with Jack.
It might also be a good idea to find a stream where someone is doing in-game voice to see if they're able to do both at once...