Have you tried it? 65,000 others have tried http://Clara.io. We've also integrated free V-Ray rendering.
PCs were not designed for 3D either compared to the old SGIs but things shifted back then. Web browsers were also not designed for email clients or word processors but we do that regularly in web browsers now as well. :)
Once two people can edit the same scene, no need for a render farm, always backed up data that is always available and the ability to embed your scene as either a render, a streaming interactive V-Ray render or a WebGL animation, using desktop software seems annoying and antiquated.
http://clara.io/ is much simpler and friendlier, but not as powerful as blender.
I almost think of it as training wheels for blender. After you work with this for long enough, you will want something more powerful.
I agree with everyone on the fact that blender might be a little difficult to learn, but now that I know it, I love it. And it is powerful.
HOWEVER! Something you may want to look into is Clara.io, it is basically a whole 3D suite in the browser. I haven't had much time to play around with it, maybe you could give it a shot (it is free).