If they're still in the same place as this video clip, then Antigua, Guatemala. (Google search of the pharmacy name that Derrick passed on his walk came up with address.)
...I've been spending too much time playing geoguessr.
Also there's a few articles around that seem to confirm that and indicate that they plan to do marriage counseling, which is kind of a WTF considering they haven't been married long (still under 2yrs.) and don't have enough familiarity with the language, let alone experience living the local culture to try to be of any real help at all in that capacity. They're still in the tourist phase of living there and of marriage. Then again, there are plenty of priests out there trying to be marriage counselors when they're unmarried and celibate, so... not unheard of for the religion end of things, but still doesn't make a damn bit of sense.