The equation is so complex and it only takes one obscurity to throw the whole formula off.
Actually, if you follow vortex optics podcasts at all, they just did a pretty interesting talk about this.
"Do suppressors affect accuracy" https://castbox.fm/vb/275900178
Loctite of any color doesn't work well under heat so that's out.
I've heard the copper anti-seize can cause corrosion on stainless steel and maybe aluminum. If your cans are titanium or regular steel it should be fine though.
Nickel anti-seize is totally non-reactive and has an even higher temp rating (though copper is plenty high). I'd just go for nickel even if you have regular steel cans because it's more likely to be suitable for other things.
I've been debating upgrading to a tumbler but wasn't sure how it would do with a monocore.
RCBS ultrasomic does a pretty good job on my 22 AR parts, Sparrow, and baffled cans (Ruger and stainless recore by ECCO machine) so not sure if it's worth the expense.
What really made a big difference was pretreating the guts with silicone. Give it a really good cleaning. Brush a bunch of silicone oil all over everything: inside of tube and endcaps, clamshell, and monocore. Wipe off the excess and slap it together. When you get home from the range, pull it apart and chuck it in the ultrasonic. Gets about 95% of the crud off.
Also, brass tools are great because they are softer than most finishes but a cuticle tool like this does a great job at getting the most stubborn lead deposits off and doesn't seem to harm the finish.
.22 LR is some of the dirtiest ammunition still in production. This leads to a great deal of carbon and lead buildup in the can, to the point that it can eventually cause obstructions.
Personally, I recommend cleaner subsonic ammunition when shooting suppressed. Additionally, I have found that applying a thin, even coating of dielectric tune-up grease to the internals of your suppressor makes cleaning much easier. (You'll still need to occasionally do a deep cleaning to remove stuck-on deposits, but most fouling will just wipe off.)