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https://www.leagueoflegends.com/en-us/news/game-updates/painted-to-life-inktale-little-legends/

A new "skinline" for tft, but maybe it will also come to lol? They have different "elements" and I had to think of Vex when I read this: "It’s lonely being the most powerful element, but it sure feels good knowing you are. Darkspark Inktales channel the colors of moody storms, and the moods of stormy tweens. You just don’t understand them yet."

That said, it's pure speculation, at the moment Pentakill Vex sounds the most likely, followed by maybe Nighbringer

Here if you wanna read it https://www.leagueoflegends.com/en-us/news/game-updates/preseason-2022-overview/

They want the inspiration tree no longer the "everyone takes it as 2nd rune because its overall good but the kaystones suck" pick. And in fact it seems inspiration works as the best 2nd rune page.

Vex’s writer literally said “I really wanted Vex to resonate with anyone with a history of depression. Who the f&^% hasn’t wanted to not get out of bed and go do what they gotta do?”

Source: https://www.leagueoflegends.com/en-us/news/dev/champion-insights-vex/

https://www.leagueoflegends.com/en-us/news/dev/ask-riot-vex-s-release-date/

Here the developers refer to her as she. So, yes. We do know.