I just remove the receptionist desk when the inspector comes, and then it bugs out and you never get penalised or any further epidemic.
Buuuuut if you don't want to cheat, there's a useful guide here. Epidemics are essentially random (a nasty event like earthquakes) so no there's no means of limiting them. One you get one, the best plan is to attempt a cover up, and pick up and drop nurses on the infected to get them cleared. Extra nurses on staff will help.
The game itself is a 16-bit DOS application. The only thing that is 32-bit can be DOSbox, the DOS emulator that comes with the game. You can try and manually replace its files with version 0.74-2 or newer (which has proper 64-bit support on macOS) if you're unsure.