game crashes pretty often for me, no error report just stops responding, happened twice in frozen city (i believe both were at the second of tanks exploding) than once on the crown screen going into 7-3 from vault. Wouldn't have brought it up but it was like 3/7 runs freezing. I haven't had or heard of this mod until today, just giving my 2 cents. Also the extra levels and weaps are awesome thanks for this
edit: oh melee seems to not affect the wolves sometimes (when rolling maybe?) couldn't find a specific reason but you can see it here @ 43:19 https://www.twitch.tv/krustykrabers/v/56685810 smack him 2 or 3 times with shovel and nothing (not sure if this is the type of thing your looking for lol but just saiyan)
Failed to replace icon
is an error that's caused by decompilers and cannot be fixed. Same goes for trying to access the Global Game Settings, it'll just throw you an exception. If you want to edit the icon, use Resource Hacker.
As for this error, it just means you didn't put the .gm81 file in the Nuclear Throne folder. It's trying to open a .dll file that isn't in the folder its on.