What are /r/longevity's favorite Products & Services?

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100 years ago, if you had breast cancer, they’d pretty much cut your entire chest off.

We’ve gone from that to using the body’s immune system to target and kill stage 4 cancer cells. That’s a huge improvement imo.

If you're looking for a book to read, The Emperor of All Maladies is fascinating.

Folding@Home is simulating this protein as I'm typing this. Everyone can help by donating their unused CPU/GPU power. More information about the project here.

Benefits may be limited to couch potatoes.

Britton A et al. 2008. Who benefits most from the cardioprotective properties of alcohol consumption—health freaks or couch potatoes?. Journal of epidemiology and community health, 62(10), pp.905-908.

However, the standard Western diet is bad enough that beer is a significant polyphenol source for many. There doesn't seem much harm in moderate consumption. Some cancers like breast increase with any drinking, but in aggregate there seems to be a hormetic effect with 1-2 drinks/d.

D3.js would be a better option, it is designed for visualizing data. I concur with /u/LankyCyril, if you'd be willing to post the data that you worked hard to collect, I'm sure someone might take the time to get something going, perhaps even on github so anyone can fork and work off of it.

There is more to protein folding than just the final state. Here is a good explanation by Greg Bowman(director of folding@home)

Check out the spreadsheet here.

It lists the 9 biomarkers used in this paper, and calculates biological age and phenotypic age.

Christ, all the news articles about this have no link to the actual paper.

Finally found it here, its available for download

There's a really interesting graph midway through the paper that shows high-stress born elephants reproducing more, earlier, but then falling off faster than lower-stress born elephants. Really interesting, the nature of stress is such a black box right now.

And to promote other ideas: there's unpaywall https://unpaywall.org/

A chrome extension that tries to find open legal versions of a paper (because sometimes the authors publish them on different websites, university pages or others)

The earliest I read is in Omni magazine, october, 1978. The article is called Some of Us May Never Die by Kathleen Stein . Omni used to be free on Archive.org, but now is available on Amazon for 3 USD. Never looked for older articles like that but is conceivable that this is not the genesis of the immortalism in its modern form. I guess it started with the counter culture.

There were also books like that one

https://www.amazon.com/No-more-dying-conquest-extension/dp/0874770556

It is the same "science finaly could solve it" argument that never materialized.

>Exactly this. I'm surprised more headlines aren't proclaiming what amazing news this is for the planet.

Some related bestsellers that just released this month False Alarm and Apocalypse Never

It will be interesting to see how governments handle the pension crisis. Liberal states overspent and tried to leverage their pension funds. Man that's a ticking time bomb and all those states will have to massively increase taxes in the upcoming months to stay afloat, much less pay pensions.

People here haven’t thought about the implications of https://www.semanticscholar.org/paper/Metformin-blunts-muscle-hypertrophy-in-response-to-Walton-Dungan/44806ab7a25af5a01ce959d85d7ac9e7a51fdb10

Starving your skeletal muscle of needed inflammation has profound implications for potential harm.

To be perfectly honest with you I just feel like the critique in the article you posted about the value of the research papers produced by folding@home is unfair. They say:

>Wikipedia has a partial list of 75 papers published drawing in some way on FAH. That is an average of 7.5 papers per year. The skeptic will notice that not a few (especially early papers, naturally) seem more concerned with FAH per se than with actual new results generated by it, and that project lead Vijay Pande seems to be author or co-author on almost all of the papers, which doesn’t indicate a large research community around the large investment of FAH. None of them seem important, and the number of publications seems to have peaked back in 2005–2006.

The fact that not every research paper "seems important", is irrelevant. A large part of science is incremental advances in seemingly 'unimportant' looking papers that have knock on effects to other fields, such as improvements in simulation techniques and the understanding of protein folding stages. Large breakthroughs often don't come from single studies, but cumulative work over many years such as this.

Looking at their list of publications for just 2021, I'd say there's a pretty solid amount of relevant research being generated.

However they are right about certain projects being more efficient than . Although it isn't purely biology per se, I contribute to QuChemPedIA@home, which seeks to train AI to increase our understanding of quantum molecular chemistry. This could help to advance both biology and things like renewable energy research, and plus they have quite a small userbase so your individual contributions are more significant haha!

Yes, this certainly isn't a slam dunk but it's another in a line of interesting research around protein levels.

This paper shows extremely unique attributes of restricting BCAAs specifically (branched-chain amino acids): https://www.docdroid.net/k71UX5i/lowbcaa-rapidfatmassloss.pdf

> "In the present study, we show that a reduced BCAA diet promotes rapid fat mass loss without calorie restriction in obese mice" > "Selective reduction of dietary BCAAs also restores glucose tolerance and insulin sensitivity toobese mice, even as they continue to consume a high-fat, high-sugar diet"

This is just mice and not humans, but certainly closer than flies. The fact that low BCAA diets reduce fat mass and improve insulin sensitivity despite no CR and high sugar/fat consumption seems to indicate that protein or BCAA restriction is the real driver of benefit in both longevity studies as well as simple weight loss.

Google "Peter Attia" he is a super knowledgable and respected MD focused on longevity and he has a podcast called the drive. If you are interested in longevity he is definitely one to listen to. In a few of his podcasts he mentions the centanarian olympics which are a series of movements he has narrowed down that are critical to the things he will be doing when he is 100. Ie. Some sort of hip hinge training so he can squat and pick up his grandkids. He touches more on it in a recent podcast he did on The Tim Ferris Show https://castbox.fm/vb/205686819

Could you take time to use Scinapse.io a little bit? The coverage's somewhat similar to that of SCOPUS or WoS, and much smaller than that of Google Scholar, but I guarantee that its search performance is great.

And if you're going to make a curated list of papers, using the Collection in Scinapse would be great. This is an exemplary one by me, you can take notes on each paper in the Collection.

https://foldingathome.org/diseases/

for starters. Obviously many labs do their own research beyond that, f@h is just something I can easily come up with of the top of my head.

Join us for a conversation with Jean Hebert, a professor of Neurogenetics at Albert Einstein College of Medicine. He is also the author of the book Replacing Aging.

We will be discussing his ambitious roadmap for curing aging by replacement of all body parts, including the brain -- his present focus.

How often do you read science books? I like to pick and choose the science books I read and if you have not read a cancer book in the last 5 years or so then it's time to read this book on cancer, this book opened my eyes to the fact that things really have changed in cancer medicine especially when it comes to immunotherapy https://www.amazon.com/Breakthrough-Immunotherapy-Race-Cure-Cancer/dp/1455568503

That book opened my eyes to the fact I didn't know how revolutionary car-t cell therapy really is even though I had already heard about it back in 2015, but also there was another major breakthrough in cancer immunotherapy have you ever heard of checkpoint inhibitors? The dude who invented checkpoint inhibitors received a Nobel prize for it just a couple of years ago that's how revolutionary the science community thinks it is they decided to give the guy Nobel prize! There's been so many breakthroughs that I see cancer being a very treatable disease within a couple of decades from now.

Well I mean at this point they have been working on this technology since the 1980s MSCs that is, I know that after a certain amount of doublings the cells become scenessed and if you don't know what that word means then just Google it. I mean I'm not a scientist I'm just a guy who likes to read about science but from what I understand they know quite a bit about the science behind all this and honestly you should watch this video the dude who discovered MSCs Arnold Caplan does a very good job explaining the science behind it https://youtu.be/qa3mMNH8Jfw

And if you have some time and you really want to geek out then read this book because it will fill you in on all the details that a geek could want to learn, this book is written by Dr Neil Riordan who has believe it or not treated famous actor Mel Gibson's father with umbilical cord MSCs! This book literally blew my mind! Just $6 on Amazon just read it on your phone https://www.amazon.com/Stem-Cell-Therapy-Disrupting-Transforming-ebook/dp/B071GRNQPX

I am 57 y.o. and have taken Tru Niagen for nearly 2 months now (first at 200 mg, now 400 mg). I give it a thumbs up for the energy boost & vivid dreams. I feel there is also cognitive improvements. There are 570 over customer reviews on Amazon, as I write. A 5-star rating has been given by 56% of the reviewers.
See: https://www.amazon.com/TRU-NIAGEN-Advanced-Nicotinamide-Increases/dp/B01IMF8D2Q?th=1#customerReviews

60 grams is around 35 dollars....

https://www.amazon.com/gp/product/B00J0H1RO2/ref=ppx_yo_dt_b_asin_title_o06_s00?ie=UTF8&psc=1

This, ladies and gentlemen, is the main reason aging happens and it is already relatively easy to fix: Identify the microbes in question and kill them.

The author has also written a book: https://www.amazon.com/Microbial-Burden-Major-Age-Related-Disease-ebook/dp/B01G48A88A/ref=sr_1_8?s=digital-text&ie=UTF8&qid=1526332350&sr=1-8&keywords=lustgarten

You can ask Aubrey de Grey , hovewer, would you like to work in molecular nanotechnology? Make CAD program for designing nanomachines for medicine?

https://www.amazon.com/Nanomedical-Device-Systems-Design-Possibilities/dp/0849374987

Well, personally I'd adopt instead of bringing new creatures into this existence, forced to live out eternity whether they like it or not, just because I couldn't be happy with not having children. Which is further increased by the fact that I have certain immune conditions like Asthma and fur allergy which I don't want to give any offspring (I myself was near-death a dozen times before I was 1 years old because of immense dust allergies when I was a baby, which I grew out of thank God). And my mothers side is fraught with early deaths in the males (as well as early balding, which I don't care about myself, but which my kid might care about a lot). The idea of having children got an entire lengthy chapter in my book about what will be the new "meaning of life" when we no longer die and simply sought to leave something behind. https://www.amazon.com/dp/B06XP5Z3W4

About the odds of reaching longevity escape velocity; That is a hard question. Cancer and stroke are probably the two really dangerous things which will stop someone from getting LEV even after SENS has succeeded for the majority of the population. So I would ask, what is your family's cancer history and cardiovascular history?

Cancer risk is only 6% inherited, 29% lifestyle and 65% random chance, http://science.sciencemag.org/content/355/6331/1266 but if you could lower your lifestyle odds by 28% and also be aware of your inherited chance then you could avoid certain things which worsen odds. Like for instance avoiding very high calorie fried food like the plague if you have a family with a history of throat and intestinal cancers. And doing cardio religiously if you have a family with high cholesterol and a history of stroke.

The best source is Natto. You also need vitamin D3 to absorb the k2 fully

i found on Amazon a good source with K2 and D3 together.

I take mainly for the arteries.. I also tried the Natto. It is not as bad as it looks.

AOR. It uses the same form in many of the clinical studies.

Best price offhand was amazon.

15 mg 90 capsules for $29.99.

https://www.amazon.com/Advanced-Orthomolecular-Research-AOR-Capsules/dp/B00457KVBM

I'm really not sure, this looked like one possibility: https://www.alibaba.com/product-detail/Qlarivia-deuterium-depleted-water_141243579.html

edit: Here's another one but this one is 115ppm, not the much better 25ppm above. And also they're all obscenely expensive. https://www.amazon.com/DDWATER-115-115ppm-500mlX8-this/dp/B0091BGKA8/ref=sr_1_1_a_it?ie=UTF8&qid=1488423786&sr=8-1&keywords=deuterium+depleted+water

Yup - I have pre-diabetic levels and am debating if I should go on metformin early or not. PCP/endos don't recommend it. Chris Masterjohn even said that he thinks it's too major of a pathway to interrupt for that long of a time. Others like Peter Attia, however, are all about it.

I'm a bit torn, but given my known condition and genetics, it might be a good gamble for me.

BTW, masterjohn recommended these B vitamins as the only ones he likes:

https://www.amazon.com/Source-Naturals-Coenzymate-Complex-Tablets/dp/B000GFPD2Y/

If you're willing to spend 10 bucks to check out the theory try getting your hands on How Not To Die. Contains approximately 4000 scientific sources backing up the main thesis that we should eat more fruits, vegetables and nuts instead of meat, dairy and eggs to live longer.

Edit: That would be evidence for a whole foods, plant based diet. A diet consisting entirely of oreo cookies and vegan ice cream would still be vegan but wouldn't last you for very long.

As I mentioned (and due to do a very large write up on over the coming weeks), live extension advocacy is on the cusp of going mainstream. David Wood of London Futurists has recently released his abolition of aging book and he (and I) are very much getting involved in the promotion of life extension advocacy in the UK as a coherent block.

Longevity news and information sites are springing up at an unprecedented rate, not to mention biotech companies. Things are quieter in the UK because we have a less market-driven heathcare system but I'm becoming aware of the happenings on the fringe here too.

Whilst I've captured a chunk of these organisations on https://hpluspedia.org, I have dozens more organisations to cross promote, put in touch with one another and increase their profiles on Wikipedia within an anti-aging narrative. Right now I am swamped.

So right now I will of course disagree about the pace of advocacy being too slow ;)