You have all kinds of people here, ranging from highschool student to bored phd chemist. I think most of us here are simply passionate about it. If you are interested I recommend Organic Chemistry by Clayden (https://www.amazon.ca/Organic-Chemistry-Jonathan-Clayden/dp/0199270295/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1597352572&sr=8-4)
It is by far, the most well explained chemistry book I have read even when my first language is not english. It's accompanied by good explanations, examples and references that are up to date and they draw links from all the work they can to actual chemistry successes in history.
"There are no discoveries, only revelations." - Dr. John C Lilly
Many monumental inventions or discoveries were by accident
Drug discovery might modulate functional biochemical groups (methylation, carboxylation, amination, acetylation, hydroxylation, oxidation, etc.) in order to mediate CNS pathways, catalysis, metabolism, agonism, antagonism, inhibition, etc. resulting in esthers, stereoisomers, racemics, polymers - intercolating bonds, shortening chains, lengthening chains, etc. Then committing novel configurations to metrology and analytical methods; GCMS, HPLC, spectrophotometry, bioassay, and so on.
I'm not a chemist but I'm learning to read it. Like a foreign language or music notation.
Machine intelligence, neural nets, algorithmic learning, predictive modeling, and such will eventually surpass human ingenuity by way of speed and efficiency - although perhaps not novelty or complexity. AI has already surpassed our visual medical accuracy in neuroimaging diagnostics. There's research online about it. It stands to reason AI will be inventing eventually.
acetic acid from sodium acetate and sulfuric acid
If you want to make acetic acid, see video above. Sodium acetate is easy to buy anhydrous sodium acetate on Amazon and you can use drain cleaner to get sulfuric acid. Nilered had a video on cleaning sulfuric acid as well. Make sure you are using anhydrous sodium acetate.
Are you trying to selectively acetylate the 6 position or would you be fine with acetylating both hydroxyl groups and making heroin?
If you don’t mind acetylating both positions, I would use acetic anhydride or acety chloride for that reaction.
If you are trying to selectively acetylate the 6 position, theoretically you can use glacial acetic acid (yes the concentration matters), along with an acid or base catalyst, but there is less literature on this reaction.
Is it brown camphor oil you're after? So, can you not just buy it:
​
Or you just want to make it as a hobby?
In the event that the pdf file moves, the new link can be found here: https://anonfiles.com/file/14b4552d3e921ed319053268a8ba5684
Completing the above paper is this correction: Correction to Total Synthesis of Lysergic Acid - 10.1021@ol500159h - 21 Feb 2014 Organic Letters volume 16 issue 4 on pages 1269 to 1269 - Umezaki, Satoshi; Yokoshima, Satoshi; Fukuyama, Tohru.pdf (111kB)
>Correction to Total Synthesis of Lysergic Acid > >Satoshi Umezaki, Satoshi Yokoshima, and Tohru Fukuyama* > >Org. Lett. 2013, 15(16), 4230−4233. DOI: 10.1021/ol4019562 > >Supporting Information > >Solvent peaks had been removed from the 1 H NMR spectra reported for compounds 20 (S33), 21 (S35), 22 (S37), and 29 (S41). Original FIDs were located, and the spectra were reprocessed and have been replaced for the above compounds in the revised Supporting Information submitted with this correction. The spectra editing did not affect any of the conclusions of the published paper. The purities calculated on the basis of the revised spectra and corrected yields are as follows: 20 (98% purity, 80% yield), 21 (97% purity, 91% yield), 22 (97% purity, 94% yield), 29 (98% purity, 72% yield).
instead of spirte bottles, why not use soda stream bottles? wouldnt that be safer?
https://www.amazon.com/Sodastream-Carbonating-Bottles-Black-Twin/dp/B003QZNABC
Well in all honesty, it's probably just easier in this case to start with GABA, just buy it in bulk from ebay or amazon. lots of other sites have it too. I found pure GABA powder here for only 30 USD for a kilogram: https://www.amazon.com/BulkSupplements-Gamma-Aminobutyric-Powder-Kilogram/dp/B00E7TWV4I
​
Then you can start with that plus an acyl chloride. Many could be done. Also, regarding GABA amide, see also progabide, a GABA prodrug which is based on the structure of GABA amide, which has benzo like activity. It is basically a hybrid of GABA amide + a benzo ring structure, attached to the amine on GABA.\
​
Some GABA prodrugs that could be really nice:
N-anisoyl-GABA (an active metabolite of aniracetam, apparently has 5HT agonist affinity) + the amide
picamilon amide (N-nicotinoyl-GABA amide)
pivagabine amide (N-pivaloyl-GABA amide)
pantogam amide (N-pantoyl-GABA amide)
> After years of buying chemicals and science products for both legitimate and illegitimate reasons, Strike has translated these experiences into book form for those that find it hard or intimidating to acquire these sorts of things. In this book are the lists of hundreds of stores and companies throughout the United States and the world that sell chemicals, laboratory products, glassware and organic precursors to both the individual and the professional. Detailed tips and explanations are given regarding purchase, shipping and governmental regulation. An enormous section is given on the usable components of common plant products, oils, commercial products and household items.
PDF converted to GIF and displayed in HTML (all in one page): http://view.samurajdata.se/psview.php?id=358df3bb&page=1&all=1