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There’s this preprint where authors hypothesise about other kinds of SSRIs on COVID
Yes, there have been studies. "mental and physical effects of lockdown covid-19" search keywords.
New data from the UK looks more like the trials suggested, though:
Certainly the best course of action is to assume limited protection until after the second dose, but as always, the real world is just messier than trials.
It's a long read - the first section of the book is a fairly detailed history of 19th Century American medicine for example. But I'm finding it pretty interesting.
The Android app link for download is here:
Also for mods: I know this post might not be a research paper, but trying to help researcher with whatever, even if little computational and processing powers our smartphones has to support such research.
Thank you.
Not published yet if i had to guess, but you can F5 here:
https://pubmed.ncbi.nlm.nih.gov/?term=Ciesek%20S&filter=years.2021-2021
https://www.semanticscholar.org/author/S.-Ciesek/5535070?sort=pub-date
Translation:
>
July 26, 2020 - 8:03 a.m.
>
>In the investigation carried out by the National Center of Epidemiology, Prevention and Control of Diseases (CDC) and the National Institute of Health (INS), it was shown that 2,700,707 people were infected with Covid-19, representing 25.3% of the population of Lima and Callao, as announced by the CDC's assistant executive, César Munayco.
>
>In addition, the specialist reported that the prevalence study made it possible to estimate the number of susceptible population, how much is left to achieve herd immunity in the assumption that SARS-CoV-2 infection produces long-lasting immunity and also to estimate the number of people to be immunized by age group when the vaccine becomes available.
>
>Munayco said that 74.7% of the population in Metropolitan Lima and Callao is still susceptible to contracting the virus, meaning that 7,974,024 people could be infected if preventive measures are not taken.
>
>On the other hand, the prevalence of Covid-19 was similar among men (21.2%: 17.9%-24.6%) and women (21.9%: 18.8%-25.0%), and higher among adolescents 24.3% (17.8%-30.8%) and young people 23.1% (18.6%-27.7%).
>
>The areas with the highest proportion of infection are: Callao 30.0% (19.8%-40.1%), Lima North 28.7% (22.6%-34.9%) and Lima East 24.4% (17.5%-31.4%). In addition, the prevalence in Central Lima was 23.1% (17.9%-28.3%) and in Southern Lima 23.3% (18.2%-28.4%).
>
>
>
>Study data
>
>The prevalence of the virus was analyzed in 43 districts of Metropolitan Lima and 7 of Callao to 3,118 people from June 28 to July 4 through serological and molecular testing by the Rapid Response Teams of the National Center for Epidemiology, Prevention and Disease Control and the DIRIS and Callao region.
Translated with www.DeepL.com/Translator (free version)
I think it's too soon for this sort of analysis to be coming out yet, though there will be a lot of sequencing going on, certainly.
As for the temperature - look at how empty of cases Africa and South America are on the map here. Doesn't look like it's doing too well in hotter temperatures so far....
FYI, it isn’t purely subjective. They are actually measuring fibrin amyloid microclots.
Millions are suffering with PASC, and we have repeated evidence now that microclotting is a cause (source, source). It’s way past time for therapies to be trialed, and these seem like logical choices. Not surprised at all that they were effective, and it will be of huge relief to many people once we get these sorts of treatments into clinical practice.
Hi guys, i work for weather.com. We're looking to speak with people who have been affected by the virus, either through a positive test, self-quarantine or caretaker. DM me if you are willing to speak with us. Can be off record. Thanks!
>Failure to provide fresh air for ventilation is curious.
Indeed.
>The average historical daily temp for Lake Burton in June is Low/High/Mean 60F/82F/71F, with high humidity. Whether electricity costs, condensation-related problems on AC systems, misconceptions about transmission, or lack of cooling capacity drove the decision not to provide fresh air is unclear, as are the what drove other policies (or lack thereof) used for mitigation at this camp.
In other countries with such a climate you don't even have A/C. In have 34°C here now and 40% rH. Windows are open (else it gets even hotter inside without A/C after a while), everything is fine.
You can easily stay outdoors with below 30°C and 40% rH - so you can also just turn off the A/C and open windows and doors all day long.
In that week the peak temperature was below 30°C with a rel. humidity of 36% - that's actually not humid, but more on the dry side. https://www.wunderground.com/dashboard/pws/KGACLAYT11/table/2020-06-28/2020-06-28/weekly
Actually the nights are a bigger problem, because it got a bit cold still and then indeed also humid.
Something like this please^^ https://www.shutterstock.com/de/video/clip-32206732-technological-red-usa-map-random-chaotic-figures
I don't think it's fake. Dr. Steve had them on an episode of his podcast recently.
u/drsteve103
FK506 (Tacrolimus) has been tested 2012 to inhibit viral growth of HCoV-NL63 and SARS-CoV, both target the ACE-2 receptor.
From what I understood UV light was a factor with SARS and MERS. So this was an early assumption made for Covid as well. I thought some tests have been conducted as well early on? But yeah I do think that people are getting hung up to much on the temperature aspect and bring it up that Covid also was/is spreading in for example Singapore where the temperatures are always high. But UV ofcourse isnt currently.
I've read a russian language interview with the lead scientist. They've done a small-scale 2nd stage trials and are beginning stage 3. The production is starting in case they get good results. So, in this sense, they are behind Oxford's vaccine by a few months.
I'd suggest reading this article addressing this very question. It is from March 6th, but I think the it is still worth reading.
There are a lot of potential reasons. The first is that Russia has very strict control over its borders as it is, with a very arduous visa process for pretty much anyone not from the former Soviet Union; on top of this, they heavily restricted travel from China, Iran, and South Korea relatively early on. Effective today, there are further limits on flights to and from Europe. Movement from affected areas is slowly being limited to allow only Russian nationals into the country, and right now, most international travelers are required to be quarantined for 14 days upon arrival either at home or at a facility, depending on where you arrive from.
It's also possible there are far more cases that have gone undiagnosed. It's hard to say for sure, but it's a possibility. This could be a result of a lot of things from false negatives to there simply being more mild cases than serious ones.
> - However why is there such a vast under reporting of 3700?
>
Underreporting is related to the lack of testing capacity. There are almost certainly some number of those deaths that are related to people avoiding seeking care until it's too late for non-C19 conditions, but I would suspect it's not a significant percentage. Without actual mortality by cause data it's impossible to know.
> - Again this still does not really count the fact, that not all people died WITH but not OF C19.
Yes, but how many weeks of +400-450% mortality do you need for that excuse to stop making sense? Most comorbid conditions that lead to higher risk of mortality with C19 are well-controlled under normal circumstances. For that matter, they're the same conditions that lead to higher risk of mortality with the flu, and flu season excess mortality in the worst years is +30-40% of baseline.
> - Also the rough numbers dont seem to change much or what is your CFR ballpark? Current total C19 deaths 17515 for NYC (https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6) still gives a ~0.85% CFR - and this is for one of the worst hotspots in the world!
IFR is percent of infected population expected to die. The fact that NYC has more cases doesn't mean you would expect a larger percentage of infected individuals to die. .85% seems a reasonable mid-range estimate. Your first post in this discussion proposed an IFR of .3%.
> - How do you account for the fact that the health system/ICU beds were overdemanded by 9x?
They never reached that point in NYC. It was bad, but the system never collapsed like it did in parts of Italy or early on in Wuhan.
Thank you this makes sense.
However why is there such a vast under reporting of 3700?
Again this still does not really count the fact, that not all people died WITH but not OF C19.
Also the rough numbers dont seem to change much or what is your CFR ballpark? Current total C19 deaths 17515 for NYC (https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6) still gives a ~0.85% CFR - and this is for one of the worst hotspots in the world!
How do you account for the fact that the health system/ICU beds were overdemanded by 9x?
I'm interested in this, is it dangerous to take Elderberry then? I found this paper, but I don't read it perfectly yet. https://www.semanticscholar.org/paper/The-effect-of-Sambucol%2C-a-black-elderberry-based%2C-Barak-Halperin/ff9e340250e4d105a5e6aea02bee5803c5580c28
> > Medicine - > Published 2009 > > # Iodine: the Forgotten Weapon Against Influenza Viruses > > David D. Derry > > After the 1918 Influenza Pandemic which killed an estimated 30 million people, governments financed research on the Pandemic's causes. Over 25 years, influenza viruses were isolated and methods for killing them with various agents discovered. Iodine was the most effective agent for killing viruses, especially influenza viruses. Aerosol iodine was found to kill viruses in sprayed mists, and solutions of iodine were equally effective. In 1945, Burnet and Stone found that putting iodine on mice snouts pre- vented the mice from being infected with live influenza virus in mists. They suggested that impregnating masks with iodine would help stop viral spread. They also recommended that medical personnel have iodine-aerosol-treated rooms for examination and treatment of highly infected patients. Current methods of dealing with influenza infection are isolation, hand washing, antiviral drugs, and vaccinations. All of these methods can be improved by incorporating iodine into them. When impregnated with iodine, masks become much more effective, and hand washing is more effect when done with mild iodine solutions. Isolation techniques coupled with aerosol iodine would make them safer for patients, medical personnel, and all persons working with the public. Public health authorities could organize the distribution of iodine and at the same time educate the public in the effective use of iodine. Oral iodine might also boost body defense mechanisms in the upper oral and respiratory mucus. Conclusion: Iodine incorporated into masks, solutions, aerosols, and oral preparations could help to kill influenza viruses and fight off an H1N1 Pan- demic. >
Explanation of this paper in layman terms: SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential
Folding@Home is also assembling this protein. They have currently found over 50 druggable pockets in the various sars-cov-2 proteins and are also helping the Covid Moonshot project to develop an antiviral.
You can download it here.
Many people have no symptoms or only mild symptoms. They can ride it out at home. Some people will need hospitalization for more serious symptoms like pneumonia. You can definitely recover. According to this tracker over 80,000 people have made recoveries out of 197,000 cases worldwide.
https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
Johns Hopkins updates several times a day, provides mapping, and pulls from multiple data sources.
https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
It's interesting to compare the mobility index of various cities with https://citymapper.com/cmi/compare
The indices were generally low during summer, around 50%, then jumped back at 70% in September. This might explain the resurgence of contagion.
That was probably when people started thinking of it seriously. But it wasn’t until about the 17th that New York really took action (when restaurants and bars closed). That was when I noticed the streets got basically empty, and other data shows a big drop off around then:
You can still be a little hopeful, but there is some word of it being unsafe for too many participants.
https://www.jbc.org/content/early/2020/04/13/jbc.RA120.013679.abstract
Ignore what OP said there, joining any (or no) team has no effect on which projects you will be assigned WU’s for. Teams are just fun for stats.
In the client, just set your disease category to “Any”. F@H prioritizes COVID work in this queue.
Well, the folding@home project has been around for 2 decades and is run by Stanford University. There is no company behind this trying to monetize user data. The computation results are shared back into the scientific community.
But in order to be really sure what's happening on your machine, you'd need to read the source code. It is open source for the most part (except for the user scoring stuff to prevent cheating).
That was true 9 days ago but it is no longer true.
>This initial wave of projects focuses on better understanding how these coronaviruses interact with the human ACE2 receptor required for viral entry into human host cells, and how researchers might be able to interfere with them through the design of new therapeutic antibodies or small molecules that might disrupt their interaction.
It should default to coronavirus folding problems.
ok, so, i have both clients installed now, but folding is taking all the CPU away from BOINC. If I turn down folding's utilization, the GPU doesn't get utilized very well. Any ideas?
EDIT: nvm, was able to make it only use one cpu core here
I found something on FAH's website: https://foldingathome.org/2020/02/27/foldinghome-takes-up-the-fight-against-covid-19-2019-ncov/
Unfortunately at this time, it doesn't seem like there's a way to dedicate cycles to just 2019-nCoV, so we're all just contributing resources to the pool of systems that "could" participate in the 2019-nCoV folding project.
Rosetta is CPU only. Folding@home and GPUgrid are two other bioscience projects which can make significant work out of your GPUs. All three projects do great work and have many publications!
Here is the design for a face shield made from a single sheet of plastic. It can be die cut or laser cut. Can produce many very quickly all over the world:
https://wikifactory.com/@adammiklosidesign/simple-face-shield
It's a sample, not a census. It's counterintuitive at first, but sample sizes don't need to increase with population size.
Try this out. Here's a program that generates two binary strings for you, one with 1000 digits and one with 1000000. We then, 50 different times, sample 20 digits from each string, and output both the proportion of 0s in the sample and the raw sample itself. Can you guess (better than random chance) if the 50 samples came from the first string or the second? If not, why do you expect the statistics gathered from these samples to be different?
Source: Personal data.
Tool: Self-reporting via Apple Watch using the Strides App. Data visualization in Excel.
Anxiety Levels: A subjective self-reported value on a scale of 1-10. I collect around 8-10 samples a day. Points on chart are daily averages.
Burps: A direct count of how many times I have burped each day.
Anyone want to participate in a documentary?
I'm a documentary filmmaker creating a feature length film composed entirely of community video submissions submitted daily as the COVID-19 pandemic progresses. We are looking for people (anyone!) to submit daily or at least frequent short videos documenting and discussing their lives during this pandemic. Everyone is in this together but experiencing so many different things, so we want to use the power of cell phones and the internet to create a global picture of how humans are fighting and coping with COVID-19.
So far we've had a lot of positive feedback about the process and many have found it therapeutic in these times.
More about the film via our sign-up page: https://airtable.com/shrMT5PyLJ8QpDFJR
PLEASE feel free to ask questions, I want to be transparent. I may not be prompt, but I will answer any questions I can. We have applications in with the International Documentary Association for fiscal sponsorship, and have a pending application for a National Geographic COVID-19 journalism grant.
My heart goes out to everyone fighting this; we're in this together.
That link for dminder doesn't seem to work at all.
Here is a link for dminder for Android in the g play store:
https://play.google.com/store/apps/details?id=com.ontometrics.dminder
I just started looking at it. It looks like a very good app..
If you have a smart phone you can also use that to fight the virus by downloading the free app Dreamlab, available for both Android and IOS.
It's like BOINC and FAH, only for phones. It's primary focus is finding treatments for cancer, but it has opened up covid19-projects too.
It takes under 5 minutes to download, install and use, it's incredibly easy to set up. It only runs when you charge your phone, and it can be set to only use wifi, or you can set and limit the amount of mobile data you want it to use (it doesn't use that much).
https://play.google.com/store/apps/details?id=au.com.vodafone.dreamlabapp&hl=en_US
You can also join other "dreamlabbers" on r/Dreamlab.
>Is it typical for a spillover event to show such high adaptation to its new host?
No, just the opposite. Spillover events almost always fail to create a chain of sustained transmission. MERS is the classic study for this, it's R0 is still <1. There has been documented human-to-human transmission, but those chains of transmission are dead ends.
If you can, get access to <strong>Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission (Current Topics in Microbiology and Immunology</strong> by Childs, the chapter on SARS discusses the biology of viral evolution in new hosts.
The key takeaways are there are two types of infection after the Zoonotic jump
First the infection of a new species resulting in disease only. This is common, think Hendra Bat Virus where the transmission chain is Flying Foxes ---> Horse ---> Human. Humans suffer infection (high fatality rate) but no Human to Human transmission has been documented.
The second type is disease and then sustained infection in the new hosts. This is very rare, and requires significant adaptation to the new host for the R0 to increase beyond 1, with rapid evolution in the virus during this process. This was documented in the case of SARS by Childs et al.
Well I’ve always used Zinc by nasal route for Colds and Flu with Zicam nasal swabs. I purchased but have not started the oral zinc pills because most come in 50mg. I would rather just use the lower dose lozenges when ever I feel I’m in high exposure areas to keep the virus from passing town the thirst into the lungs. In order to use the lozenges I can’t take the oral pills due to risk of to many milligrams a day of Zinc. I will use the Vitamin C instead for prophylactic effect. The lozenges I purchased on Amazon yesterday ate now sold out today but maybe they are sold elsewhere. I liken them because they were 9mg so could use more often to coat my throat. zinc lozenges